BOTTOM LINE: In the CDC report, which analyzed COVID-19 cases in California and New York in 2021 from May 30 to November 20, the scientists compared the risk of new SARS-CoV-2 infection among four groups of people: those who were unvaccinated without a prior case of COVID-19; those vaccinated without prior COVID-19; those unvaccinated with prior COVID-19 and those vaccinated with prior COVID-19.
The authors explain that before the emergence of the delta variant of SARS-CoV-2, recent vaccination was more protective against new infection than natural immunity (in California during June, for example, 20.9-fold vs 8.2-fold). However, after delta became prevalent, natural immunity was more protective against infection than vaccination (in California during September, 8.3-fold vs 35.0-fold).
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